New answers on PD-L1
February 2017
SHARING OPTIONS:

HOUSTON—Recent work from scientists at MD Anderson Cancer Center, led by Dr. Mien-Chie Hung, chair of Molecular and Cellular Oncology, has uncovered new insight into how PD-L1 suppresses the immune system. The team found a previously unknown immunosuppression mechanism in cancer cells: inhibition of protein CSN5 activity blocked PD-L1’s ability to avoid the immune system. Specifically, CSN5 affects PD-L1’s interaction with PD-1, a cell receptor that blocks T cell activation when it binds with PD-L1. TNFa was also found to impact CSN5’s ability to ‘stabilize’ PD-L1 and boost its interaction with PD-1.
 
“This regulatory event is critical for breast cancer cells to escape immune surveillance via interaction between PD-L1 and PD-1,” Hung explained. “Importantly, inhibition of TNFa-mediated PD-L1 stabilization in cancer cells promotes the tumor-infiltrating immune response. Thus, targeting cancer cell PD-L1 stabilization through CSN5 inhibition could help us develop better treatments for cancer accompanied by inflammation.”

Back
 
CONTACT US
DDNEWS
1000 N West Street, Suite 1200,
Wilmington, Delaware, 19801
Ph: 888-781-0328 |  Fax: 705-528-0270
 
© Copyright 2020 Old River Publications LLC. All righs reserved.  |  Web site managed and designed by OffWhite.