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Horizon Discovery to collaborate with NCI, NHGRI
January 2012
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CAMBRIDGE—Horizon Discovery recently entered into a three-year Technology Access Agreement with the National Cancer Institute (NCI) and the National Human Genome Research Institute (NHGRI) of the U.S. National Institutes of Health, with a focus on enabling the NCI and NHGRI to apply Horizon's rAAV gene-editing technology to engineer human isogenic disease models. The project will seek to generate tens of new X-MAN cell lines each year, and the first set of 18 projects will focus on developing disease models for prostate, melanoma, kidney and colon cancer, genes involved with chromatin and chromosome function and cell lines complementary to existing mouse cancer disease models. Horizon will work with the NHGRI to develop the disease models for melanoma, and the NCI will serve as a Center of Excellence in gene editing, with a core research group providing disease models for the investigators at the NCI. Financial details were not disclosed.  


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