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New tactic could circumvent hiPSC mutation
October 2014
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DURHAM, N.C.— A recent study by researchers at Tokyo Medical and Dental University and Osaka University has detailed a discovery that might avoid the tendency of human induced pluripotent stem cells (hiPSCs) to mutate. Stem cells are induced to become different types of cells through the use of what is known as a reprogramming transgene, and the team, led by Dr. Ken Igawa, discovered that by removing this material after differentiation, stem cell mutation could be avoided. When the researchers compared transgene-free hiPSC lines with those still containing reprogramming material, they found that the former presented more like normal human cells than the latter. The article, “Removal of Reprogramming Transgenes Improves the Tissue Reconstitution Potential of Keratinocytes Generated From Human Induced Pluripotent Stem Cells,” was published in STEM CELLS Translational Medicine.
 
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