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NYSCF team creates bone grafts from skin cells
June 2013
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NEW YORK—A team of researchers from the New York Stem Cell Foundation Research Institute have reported the successful generation of patient-specific bone substitutes from skin cells, which were successfully transplanted into living mice. The researchers reprogrammed adult skin cells into induced pluripotent stem (iPS) cells, then guided them to become bone-forming progenitors, which were then placed on a scaffold for three-dimensional bone formation. These constructs were then placed in a bioreactor, which mimics a natural developmental environment while providing nutrients and removing waste. The bone substitutes were transplanted into immunocompromised mice, and after 12 weeks, the bone tissue completely matured and blood vessel cells began to integrate along the grafts. In addition, though undifferentiated iPS cells can form tumors, no malignancies were seen after the 12 weeks.

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