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Cellular Dynamics stikes agreement with AstraZeneca to use iPSC-derived human cells in drug discovery research
MADISON, Wis.—Cellular Dynamics International Inc. (CDI) recently announced a Center of Excellence agreement with AstraZeneca to accelerate the pace of drug discovery through the use of human induced pluripotent stem cell (iPSC) lines and tissue cells.
As CDI notes, "
iPSC technology, based on reprogramming adult cells from a simple blood sample or a skin biopsy to a pluripotent stem cell state, shows promise in delivering robust human cell models of high utility in drug discovery and without the ethical concerns linked to the use of human embryonic stem cells, and
Steve Rees, vice president of Screening Sciences & Sample Management, Discovery Sciences at AstraZeneca, adds that "This agreement with Cellular Dynamics enables AstraZeneca to access world-leading expertise in stem cell technology so that we can better test potential new medicines for safety and efficacy."
Under the terms of the Center of Excellence agreement, AstraZeneca will take advantage of commercially available iCell products and CDI's recently launched MyCell Products for iPSC reprogramming and differentiation, and the two parties will collaborate on the development of one or more novel cell types. AstraZeneca will purchase CDI's commercially available iCell products, including iCell Cardiomyocytes, iCell Neurons, iCell Endothelial Cells, and iCell Hepatocytes, for use in their safety, discovery, and regenerative medicine programs. Furthermore, AstraZeneca will rely on CDI's novel MyCell Products to genetically engineer and manufacture cells from specific patient groups for use as in-vitro disease models.
In addition, CDI will work in partnership with AstraZeneca toward development of one or more new iPSC-derived cell types to enable novel discovery screening applications. Financial terms of the agreement, however, remain undisclosed.
"This is the third Center of Excellence agreement we have entered into with a global pharma company, and these partnerships show customer recognition that leveraging CDI's technical expertise and resources can help accelerate their discoveries," said Bob Palay, CEO of CDI. "We are excited that AstraZeneca shares our vision that iPSC technology can be transformative. The Center of Excellence agreements show CDI's leadership in developing best practices to employ human iPSCs to advance healthcare discoveries."
To this, CDI's chief commercial officer, Chris Parker, added, "Increasingly customers are recognizing CDI's focus and investment on industrializing the manufacture of iPSC-derived cells. Utilizing these standardized cellular tools enables customers like AstraZeneca to concentrate on developing therapies rather than manufacturing cell types."
SOURCE: CDI/AstraZeneca news release