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New reagents enable optimal digestion, method development and instrument monitoring for LC/MS
Promega launches new products for scientists working with mass spectrometry. The IdeS Protease enables fast, easy, high-performance digestion of immunoglobulin, while the human and yeast protein extracts provide a test material for optimizing mass spec sample preparation. The new products add to the company’s existing range of proteases and services to improve mass spec sample prep workflows.
IdeS Protease is a recombinant, engineered version of the immunoglobulin-degrading enzyme from Streptococcus pyogenes. It is a highly specific protease that slices immunoglobulin G (IgG) at a single, targeted site, offering 100 percent digestion in 30 minutes with no optimization. IdeS can be used to characterize therapeutic antibody candidates using LC/MS, and contains a histidine tag for easy removal. The versatile Promega IdeS enzyme cuts IgGs from a range of species, as well as Fc-fusion proteins.