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New modular membrane chromatography solution for large-scale applications
November 2017
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Sartorius Stedim
 
New Sartobind cassettes offer the same flow path, bed heights (4 and 8 mm) and void volume ratios as Sartobind capsules, and are compatible with Q, S, STIC PA and phenyl ligands. The new design goes beyond the previous 5 L size limitation for capsule formats, expanding the boundaries of membrane chromatography. Multiple cassettes, each with 0.8 L or 1.6 L membrane volume, can be set up in three different stainless steel holders resulting in maximum membrane volumes of 20, 50 or 100 L, respectively.
Data demonstrates direct scalability from the 3 mL Sartobind nano capsule to 20.8 L (13 cassettes) in the Pilot Filter Holder. Pressure-flow performance and the shape of breakthrough curves are identical to the smaller capsule sizes, independent of the number of cassettes used. Set up can be accomplished within minutes, even at manufacturing scale, whether for capture applications or for flow-through removal of process contaminants.
 
Sartorius Stedim

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