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No more ‘garbage in, garbage out’
July 2012
SHARING OPTIONS:
WESTMINSTER, Colo.—Flagship Biosciences is expanding its
reach into immunohistochemistry (IHC) and histology with the recent acquisition
of IHCtech. The companies say they will work on a number of new techniques and
approaches for quantitation in immunohistochemistry.
Financial terms of the deal were not disclosed.
According to Flagship CEO Steve Potts, the company was founded to deliver quantitative digital results in
pharmaceutical pathology, marrying image analysis expertise with veterinary and
anatomic pathology.
“We have built a network of more
than a dozen IHC laboratories, many of them CLIA laboratories with specialties
in areas like hematopathology, dermatopathology or gastrointestinal disease,”
he says. “However, it has been clear that despite the advanced approaches in
digital imaging, the data and results are only as good as the underlying
histology and tissue processing. Garbage in, garbage out.”
Potts says the time was right for the acquisition, coming on
the heels of what he describes as “a 10-year
revolution going on in pathology similar to what happened in the 1990s in
radiology.”
“The discipline is going digital,”
he says. “There are approximately 100 million glass slides per year used in
pharmaceutical research, from discovery through toxicology testing and into
oncology clinical trials.”
David Young, president of Flagship, says while his company
has forged strong partnerships with a number of highly respected IHC
laboratories, both within the United States and internationally, “the
acquisition gives us the opportunity to internally evaluate tissue staining and
implement new processes that better equip immunohistochemistry operations for
use in quantitative pathology with whole-slide imaging analysis.”
The acquisition gives Flagship an
operating center right in the Aurora, Colo.-based Anschutz Medical Campus, a
fast growing center of clinical operations in the Rocky Mountain region.
“We are also building a large
laboratory near the Phoenix International Airport,” says Potts. “The locations
of these two laboratories right by major airports are no accident. Tissue
analysis is a logistics business, and being a taxi ride from major airline hubs
is a major advantage to preserving tissue quality and faster turnaround.”
Flagship will retain IHCtech’s
employees, he adds.
“We will continue to keep the
branding of IHCtech, as its owner, Patsy Ruegg, has built a strong reputation
for high-quality and excellent customized work in discovery IHC and dual and
triple staining,” he says.
Founded in 2002, IHCtech has developed a reputation for
advanced IHC and histology procedures, meeting the needs of pharmaceutical and
academic investigators. IHCtech has optimized more
than 350 antibodies for pharma and academic clients, says Ruegg, the
company’s owner and founder.
“Their approaches to whole-slide analysis and commitment to
quantitative pathology makes a perfect partner with IHCtech’s expertise in
high-quality histology and immunohistochemistry,” she says. “We
enthusiastically look to further innovation by evaluating all aspects of the
tissue chain—tissue procurement, fixation and processing, with the ability to
measure with whole-slide analysis how each of these steps contribute to
variability in the overall process.”
Potts notes that “most of these
350 antibodies are things the clinic has not heard of, although some are ones
that will eventually make the clinic in pharma companion diagnostic programs.”
Going forward, Potts says a
short-term goal is to integrate all the companies’ digital processes into one
histology operation.
“We have a tissue-tracking
electronic system similar to the Amazon ‘Where’s My Stuff’ or FedEx tracking—so
we know which stage our projects at in—from tissue procurement, to tissue
processing, to IHC, to whole-slide scanning, to image analysis and pathologist
report and biostatistics,” he says.
The combined companies hope to
reinvent how histology is approached, with every change to the tissue
standardized and measured with image analysis downstream.
“There are a number of exciting
innovations we are working on related to new approaches in histology opened by
a digital end product,” Potts says.
Potts adds that Flagship continues
to consider additional acquisitions that fit into its goal of being the
preeminent tissue analysis services company in the pharmaceutical sector.
“There simply are not very many
IHC laboratories that have the expertise in discovery IHC that is only
developed with years of practices,” he says. “It is far easier to purchase
histology equipment than it is to find expert histologists who understand that
everything you do to a piece of tissue will affect the end result when it is
measured by a computer.”
Code: E071209 Back |
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