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Increased consistency in cell culture manufacturing
January 2010
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SAFC Biosciences
 
SAFC Biosciences, a business segment of SAFC, a member of the Sigma-Aldrich Group, has introduced EX-CELL ANTIFOAM, a non-animal origin solution that enhances foam control in cell culture bioreactors to increase the consistency, efficiency and stability in cell culture manufacturing. The solution is formulated from a 30 percent simethicone emulsion and validated by a simethicone quantification assay that confirms lot-specific concentration. This USP grade, non-ionic emulsion (simethicone) is designed for use in the pharmaceutical and veterinary biological industries to aid in the control of cell culture foaming in bioreactors. Through formulation optimization, utilization of a quantitative assay and understanding the non-specific binding of simethicone, SAFC Biosciences is able to report the actual simethicone concentration of the gamma irradiated finished material, producing a stable end product, thus ensuring product consistency, predictability and desired performance with at least a 13-month shelf life. EX-CELL ANTIFOAM is ready to use and should be directly supplemented into culture systems to prevent or eliminate foaming that occurs due to mixing and shear forces. The solution is available in 1- and 5-liter bags.
 
SAFC Biosciences
(800) 244-1173
www.safcbiosciences.com/antifoam 
 

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