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Toxicity predictions
January 2020
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BOSTON—When evaluated with eight previously studied drugs, Emulate Inc.’s Liver-Chip was able to accurately model and predict human toxicity, the company announced in November. In addition to predicting liver toxicity differences between humans, dogs and rats, the Liver-Chip was also able to model the mechanism of action for hepatotoxicity and measure relevant clinical biomarkers. This research examined drugs that had advanced to human trials with no signs of toxicity in animal studies, but that were then halted during in-human studies due to safety concerns. The Liver-Chip accurately predicted the drugs that demonstrated human toxicity despite not showing any hepatotoxicity concerns in animal studies. The results, published in Science Translational Medicine, were co-authored by researchers from AstraZeneca, Janssen Research & Development, LLC, the Wyss Institute for Biologically Inspired Engineering at Harvard University, and Emulate.

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