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V-101 demonstrates neurogenesis in rodent models
March 2019
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SOUTH SAN FRANCISCO, Calif.—Recent nonclinical studies have shown that AV-101 (4-chlorokynurenine) can promote hippocampal neurogenesis (the formation of new neurons), VistaGen Therapeutics announced recently. The studies were conducted on rodents, who received oral daily dosing of AV-101 for 14-16 days and showed increased neurogenesis, as monitored by an increase in the number of cells with Ki67, a marker of dividing cells. The rats were scored by scientists blinded to the treatment groups.
 
“The development of new neurons is a vital part of our mental growth during adulthood, and the exciting results of these nonclinical studies highlight AV-101’s potential to promote adult hippocampal neurogenesis. We believe these results are potentially far-reaching, especially given that enhanced hippocampal cell proliferation provides protection against stress-related psychiatric disorders, including depression,” said Shawn Singh, CEO of VistaGen.

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