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Positive data for TRC105
SAN DIEGO—TRACON Pharmaceuticals, a clinical stage biopharmaceutical company focused on the development and commercialization of novel targeted therapeutics for cancer, wet age-related macular degeneration and fibrotic diseases, in late January announced that positive clinical data from its ongoing Phase 1b/2 study of TRC105 and Nexavar (sorafenib) in patients with advanced hepatocellular carcinoma (HCC) were presented in a poster presentation at the ASCO 2019 Gastrointestinal Cancers Symposium in San Francisco.
Data from the ongoing open-label, non-randomized study were presented by Dr. Kanwal Raghav from the University of Texas MD Anderson Cancer Center. Key results included:
“We continue to be encouraged by the safety and activity of TRC105 in combination with Nexavar in patients with liver cancer,” said Dr. Charles Theuer, president and CEO of TRACON. “Importantly, the response rate from the current trial is superior to historic response rates reported from multiple trials of Nexavar as a single agent. We expect to complete enrollment of the current multicenter study by the end of this year, at which time we expect to correlate response with the soluble baseline biomarkers that are being collected as part of the study.”